Lupus: Open Access
Open Access
ISSN: 2684-1630
ISSN: 2684-1630
SLE is a SLE is a chronic autoimmune illness marked by the activation of both innate and adaptive immunological responses, which can result in serious organ damage. Although the cause of autoimmunity in SLE is unknown, natural immune responses in SLE have been linked to abnormalities in apoptotic clearance, loss of tolerance, and a type I interferon (IFN) profile. Type I IFNs are mainly generated by plasmacytoid dendritic cells in response to immunological components and Neutrophil Extracellular Traps (NETs) formed during neutrophil NETosis. SLE also exhibits systemic inflammation, with elevated levels of pro-inflammatory cytokines that include Tumour Necrosis Factor (TNF)-, interleukin (IL)-6, and IFN-α, Induced Protein (IP)-10. autoimmune illness marked by the activation of both innate and adaptive immunological responses, which can result in serious organ damage. Although the cause of autoimmunity in SLE is unknown, natural immune responses in SLE have been linked to abnormalities in apoptotic clearance, loss of tolerance, and a type I interferon (IFN) profile. Type I IFNs are mainly generated by plasmacytoid dendritic cells in response to immunological components and Neutrophil Extracellular Traps (NETs) formed during neutrophil NETosis. SLE also exhibits systemic inflammation, with elevated levels of pro-inflammatory cytokines that include Tumour Necrosis Factor (TNF)-, interleukin (IL)-6, and IFN-α, Induced Protein (IP)-10.
Published Date: 2023-07-04; Received Date: 2023-06-01