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The aim of this study was to evaluate chemopreventive potential of Coffee arabica in DMH-induced colorectal carcinogenesis in the rat model. Totally, 35 female wistar rats were divided into seven equal groups. Groups I-VII except group VI were given freshly prepared neutral DMH in normal saline, once a week for 5 weeks. Group VI received normal saline alone. Groups II and III received oral dose of coffee every time when they are given DMH. Groups IV and V received coffee after 5 months of DMH treatment. Group VII was treated with aspirin. Multiple plaque lesions, aberrant crypts and aberrant crypt foci were observed in colorectal walls of the DMH alone treated rat groups. The numbers of preneoplastic features were significantly reduced in coffee or aspirin treated groups. Histologically, different degree of dysplasia and hyperplasia was observed in DMH alone group. The above features were significantly reduced in coffee or aspirin treated groups. Serum biomarkers and body weight of DMH-induced colorectal cancer were appreciably maintained in coffee and aspirin treated groups. Taken together, the results of this study revealed that Coffee arabica has significant effect on reducing the number of preneoplastic lesions and polyps, considerably suppressing tumor progression and invasion.