The future of medical education is highly dependent on the quality of teaching tools employed by the educators. Textbooks are vital tools for teaching as they are valuable resources in the process of education. The basic medical sciences forms the foundation for medical training, and Physiology education is key. Nigerian (and indeed African) medical instructors are highly dependent on the developed world for the textbooks and research materials they employ in training their students. They common Physiology textbooks they use are mostly by non-African authors. These textbooks as beautiful and voluminous as they appear fail to fully capture information that reflect some of the pathophysiological peculiarities of the Nigerian/African population. Such an information gap has the capacity of creating a disconnect between the actual knowledge acquired in school and the practical situation present in the society. Considering the current paucity of research work from local authors there is need for more pro-activeness from indigenous researchers to bridge such gaps. Both government and private sector participation is also needed towards supporting the writing of physiology textbooks with a broader all-encompassing approach. This is a step that can pave way for an academic revolution not only in Nigeria but in the entire African continent.