Drug Designing: Open Access
Open Access

Abstract

Biomolecular Condensates as Drug Targets: The Next Phase in Intracellular Drug Design

Lukas Neumann*

The recognition of biomolecular condensates as critical organizers of cellular biochemistry has opened an exciting frontier in drug discovery. These non-membranous compartments, formed via liquid liquid phase separation, compartmentalize biomolecules such as proteins and RNA into dynamic, often transient assemblies that regulate essential processes like gene expression, signal transduction, and stress responses. Unlike traditional organelles, biomolecular condensates lack physical boundaries and are governed by weak multivalent interactions, enabling rapid reorganization in response to physiological cues. This unique mode of organization offers novel opportunities for therapeutic intervention, especially as aberrant condensate behavior is increasingly linked to diseases such as cancer, neurodegeneration, and viral infection.

Published Date: 2025-03-04; Received Date: 2025-02-03