Biochemistry & Pharmacology: Open Access
Open Access

Abstract

Biochemical Alteration Induced After Intramuscular Administration of Long Acting Moxifloxacin in Sheep

Chirag M Modi, Shailesh K Mody and Hitesh B Patel

The present study was conducted with objective to study biochemical alterations induced after single intramuscular administration of long acting moxifloxacin at the dose rate of 7.5 mg/kg body weight in six healthy male sheep. After deep intramuscular injection of moxifloxacin, blood samples in collected K3EDTA at 0, 6, 12 hour and 2, 3,4, 5,6,7th day after treatment were analyzed for biochemical Aspartate Aminotransferase (AST) Alanine aminotransferase (ALT), Alkaline Phosphatase (AKP), Acid Phosphatase (ACP), plasma creatinine, plasma Creatine kinase-MB, Blood glucose and Total bilirubin) analysis. The results of the study clearly demonstrated that single intramuscular administration of long acting moxifloxacin in sheep at 7.5 mg/kg body weight did not cause any significant change in values of biochemical parameters in sheep with total absent of clinical signs of adverse reactions or toxicity.