Biochemistry & Pharmacology: Open Access
Open Access

Abstract

Anti-Hyperglycemic Potency of Jatropha Gossypiifolia in Alloxan Induced Diabetes

Adetuyi BO, Dairo JO and Didunyemi OM

The aqueous extract of Jatropha gossypiifolia were studied for their anti-hyperglycemic activity, fifteen animals were taken and they were divided into five groups. First group act as the control, while the remaining four groups were induced diabetics by administering alloxan (120 mg/kg). Second group induced with diabetes with insulin treatment, third group induced with diabetes without treatment, fourth was infected with diabetes treated with 12 hours intervals oral dose of ethanolic extract of leaves (120 mg/kgbody weight) and fifth group was infected with diabetes treated with 12 hours intervals oral dose of ethanolic extract of leaves (240 mg/kg body weight/day). From the experiments, It was discovered that the aqueous extract of Jatropha gossypiifolia at dose of 120 mg/kg and 240 mg/kg for 7 days has effects in reducing hyperglycemia, it was discovered that the body weight increased, in line with one of the symptoms of diabetes; obesity. The test carried out on three different types of microbes shows that the aqueous extract inhibit the growth of the micro-organisms at different concentration. Staphylococcus aureus is a gram +ve bacteria, this can be seen in the low zone of inhibition seen in Klebsiella pneumonia (gram -ve ) and also Escherichia coli is a gram – ve. It was also discovered that the ethanolic extracts of Jatropha Gossypiifolia have a phytotoxic effect; that is, they inhibit the growth of plants as compared to the control. This could be trace to the difference in the phytochemical components of the ethanolic extract, alkaloids, tannins, saponins and glucosides are discovered to be present in the ethanolic extract.