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Aim of the present study was to observe the effect of Indian red scorpion venom (SV) in the treatment of Freund’s complete adjuvant (FCA) induced arthritis and collagen type II (CII) induced arthritis models in rats. The immunosuppressant action of SV was confirmed by hemagglutination antibody titre. The further results also suggest that SV produce analgesia in both developing and developed phases of arthritis when evaluated on various pain perception models. SV significantly reduced the paw edema volume and ankle joint diameter in arthritic paw of rats. The altered hematological and biochemical parameters were brought to normal by SV in arthritic conditions when tested on experimental animals. Further anti-arthritic activity of SV was confirmed from the histopathological and radiological findings.