ISSN: 2161-1149 (Printed)
Acute rheumatic fever is prevalent across the world and carries a high mortality and morbidity predominantly due to its complication of carditis. The underlying pathogenesis involves a complex interaction between the infective agent and the immune system. Traditionally, management has focused on preventing recurrent infections by prophylactic antibiotics. We illustrate two cases managed with immunosuppression which can be a valuable additional tool in managing this global health problem.