A novel flocculant based on polyacrylamide-poly aluminum silicate sulfate (PAM-PASS) has been synthesized using a redox initiation system ((NH4)2S2O8?NaHSO3) at 40? in aqueous medium. In this paper, the influence of the concentration of acrylamide, the mole ratio of aluminum to silicon, and pH value on the activation of silicate, which was prepared with the sodium silicate with the modulus of 3.3, was investigated. The results showed that the optimal process conditions for preparing PAM-PASS were as follows: silica concentration of 7%, aluminum silicon ratio of 3:1, and pH value of 3.0, acrylamide mass fraction of 20.7% of total material, aluminum hydroxide accounted for 7.5% of total material quality score with ammonium persulfate and sodium bisulfite as initiator, reaction temperature 40?, PAM - PASS the synthesis of 3 hours. The PAM-PASS was prepared at the optimal conditions mentioned above and used for the treatment of waste water. The rates of turbidity and color removal were 99.6% and 98.2%. Place the PAM - PASS in the air for 100 days the rate of deturbidity in a more than 90%. Respectively, when the dosage of PAM-PASS was 15 mg/L. The PAM-PASS was characterized by viscometer, IR spectroscopy, TEM, SEM, conductivity, and TGA. It was found that an ionic bond exists between Al colloid and polyacrylamide (PAM) chains in the PAM-PASS; Silicon and aluminum form the amorphous polymer and the flocculation efficiency of PAM-PASS is much better than that of commercial polyacrylamide (PAM) and PASS.