Marek Malecki, MD PhD
President, Genetic and Biomolecular Engineering
PBMEF, San Francisco, USA
Alex F Chen, MD, PhD, FAHA
Director, Department of Surgery
University of Pittsburgh School of Medicine, Pittsburgh, USA
Professor and Endowed (Funded) Chair of Nutrigenomics and Growth Biology, Department of Animal Sciences, School of Molecular Biosciences
Washington State University, Pullman, WA, USA
Journal Impact Factor 2.2*
Submit manuscript at www.longdom.org/submissions/stem-cell-research-therapy.html or send as an e-mail attachment to the Editorial Office at [email protected]
Table of Contents
About the Journal
PUBMED NLM ID: 101586297 | Index Copernicus Value: 84.95
The Journal of Stem Cell Research & Therapy is an open access journal that showcases seminal research in the field of stem cell therapy. As stem-cells are flag-bearers of translational research, the field has an interdisciplinary feel by including oncology, clinical research, medicine and healthcare under the aegis of stem-cell therapy. It also includes scientific research related to the auxiliary areas of Biology by prioritizing scholarly communication milieu and transfers expert knowledge synthesized from the ever burgeoning stem-cell literature.
In order to create such impactful content, the Journal of Stem Cell Research & Therapy brings together an expert Editorial Board, which comprises of noted scholars in the field of Cell Biology. Every single article is subjected to rigorous peer review by illustrious scientists. In addition to Research Articles, the Journal also publishes high quality Commentaries, Reviews, and Perspectives aimed at synthesizing the latest developments in the field, and putting forward new theories in order to provoke debates amongst the scholars in the field. The journal thus maintains the highest standards in terms of quality and comprehensive in its approach.
The journal aims to provide the authors with an efficient and courteous editorial platform. The authors can be assured of an expeditious publishing process. In this regard, the journal also provides advance online posting of the accepted articles. The Journal of Stem Cell Research & Therapy ensures barrier-free, open access distribution of its content online and thus, helps in improving the citations for authors and attaining a good impact factor.
Stem Cell Technologies
Stem cell technology is developing very rapidly which combines the efforts of cell biologists, geneticists, and clinicians and gives us hope of effective treatment for a variety of malignant and non-malignant diseases. For Example, the ability of tissue stem cells to integrate into the tissue cyto-architecture under the control of the host microenvironment and developmental cues makes them ideal for cell replacement therapy.
Bone Marrow Stem Cells
Bone Marrow Stem Cells Bone marrow is the soft, sponge-like material found inside bones. It contains immature cells known as hematopoietic or blood-forming stem cells. Bone marrow transplantation is a procedure that restores stem cells that have been destroyed by high doses of chemotherapy and/or radiation therapy. Bone marrow or stem cell transplants are used to treat some types of leukaemia or lymphoma, and myeloma.
The endothelium is the thin layer of simple squamous cells that lines the interior surface of blood vessels and lymphatic vessels, cells that form the endothelium are called endothelial cells. The main function of endothelial cells is to provide a barrier between the blood and the rest of the body tissues. The endothelial cells act like a sieve, restricting the passage of large molecules, toxic substances and bacteria into the brain tissue while allowing necessary molecules like oxygen, enzymes and hormones.
Stem Cells: Controversies and Regulation
The stem cell controversy is the consideration of the ethics of research involving the development, usage, and destruction of human embryos. The controversy centered on the moral implications of destroying human embryos. Many funding and research restrictions on embryonic cell research will not impact research on induced pluripotent stem cells allowing for a promising portion of the field of research to continue relatively unhindered by the ethical issues of embryonic research.
Hair Stem Cell
Hair follicles also contain stem cells, and some researchers predict research on these follicle stem cells may lead to successes in treating baldness through an activation of the stem cells progenitor cells. Stem-cell therapy led to a significant and visible improvement in follicular hair growth. New hair grew effectively using human pluripotent stem cells, cells derived from human embryos or human fetal tissue that can become any other cell type in the body.
Stem Cell Therapy
Stem cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most widely used stem cell therapy. Bone-marrow has been used to treat cancer patients with conditions such as leukaemia and lymphoma. Stem cell treatment protocols employ well-targeted combinations of allogeneic human umbilical cord stem cells, autologous bone marrow stem cells, and autologous adipose stem cells, and to treat the diseases.
Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function. Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and safely implanting them when the body cannot heal itself. Examples include the injection of stem cells or progenitor cells obtained through Directed differentiation.
Adult Stem Cells
Adult stem cells are undifferentiated cells found throughout the body that divide to replenish dying cells and regenerate damaged tissues. An adult stem cell is an unspecialised cell that is capable of Long term renewal and Differentiation into specialised cell types. The primary function of adult (somatic) stem cells is to maintain tissue homeostasis by replenishing senescent or damaged cells. They are also known as somatic stem cells, they can be found in children, as well as adults.
Pancreatic Stem Cells
The endocrine pancreas represents an interesting arena for regenerative medicine and cell therapeutics. One of the major pancreatic diseases, diabetes mellitus is a metabolic disorder caused by having an insufficient number of insulin-producing β cells. Replenishment of β cells by cell transplantation can restore normal metabolic control.
Murine Embryonic Stem Cells
Molecular regulation of embryonic stem cell fate involves a coordinated interaction between epigenetic transcriptional and translational mechanisms. It is unclear how these different molecular regulatory mechanisms interact to regulate changes in stem cell fate.
Please go through the Journal highlights for more relevant fields of Stem Cell which can be considered for publication within the scope of Journal.
Current Issue Highlights
Robust, Efficient and Pure Induced Mesenchymal Stem Cells Generation from mRNA Induced Pluripotent Stem Cells in Suspension
Rajneesh Verma, Pornpun Saengmuang, Tanabodee Payuha, Julie D Mendoza, Rotsarin Narang, Naphapatsorn Bondee, Sergei Dmitrievs, Paul Michael Collier