Journal of Vaccines & Vaccination

Therapeutic potential of natural adjuvants PC, G2 and G2F vaccine on asthma, basic and clinical evidences

5^th Asia Pacific Global Summit and Expo on Vaccines & Vaccination

July 27-29, 2015 Brisbane, Australia

Mohammad Hossien Boskabady1, Jalil Tavakol Afshari2, Ali Neamati3 and Saleh Mohaghegh Hazrati4

Posters-Accepted Abstracts: J Vaccines Vaccin

Abstract:

PC adjuvant is a bacterial extract polypeptide, G2 adjuvant was prepared from buffalo spleen lipid and G2F preparation is the crude Sesame seed oil, all registered as a patent in the Iranian Patent Office as: Immune System Activator Vaccine with well known immune-regulatory effect agents. In a seris of studies the effects of natural adjuvants vaccines PC, G2 and G2F on tracheal responsiveness to methacholine and ovalbumin, total and differential WBC counts, of lung lavage, the level of IL-4 and IFN-? in serum and Th1/Th2 balance as well as pathological changes in sensitized guinea pigs, an animal model of asthma were shown. The effects of PC, G2 and their combination on total and differential WBC counts as well as the level of IL-4 and IFN-? in, in lung lavage and lung pathology of ovalbumin sensitized BALB/c mice were also documented. The effects of natural adjuvants in asthmatic patients in a large clinical trial on asthma symptoms, pulmonary function tests eosinophil counts and some inflammatory mediators were also investigated. The effect of G2 vaccine on treatment of oral lichen planus also showed reduction of patient?s symptoms and increase in CD4+counts and rise in CD4+/CD8+ ratio. These results indicate therapeutic potential of natural adjuvants and their combination on sensitized animals and asthmatic patients as well as other inflammatory disorders associated with Th1/Th2 imbalance.