Journal of Clinical & Experimental Pharmacology

The role of nicotinic receptors in the effects of galangin in the Morris water maze

8^th World Congress on Pharmacology and Toxicology

July 24-25, 2017 Melbourne, Australia

Fatma Sultan Kilic, Sule Aydin, Engin Yildirim, Setenay Oner, Kevser Erol and Bilgin Kaygisiz

Eskisehir Osmangazi University, Turkey

Posters & Accepted Abstracts: Clin Exp Pharmacol

Abstract:

Introduction & Aim: Enhancing cholinergic transmission is suggested to improve cognitive functions. We aimed to investigate the effects of galangin, a flavonoid compound that is reported to inhibit acetylcholinesterase enzyme, on mecamylamineinduced spatial memory impairments in rats. Methods: Morris water maze test was used to investigate the spatial memory. Galangin 50 (100 mg/kg) was administered acutely 30 minutes before the impairment of spatial memory by a nicotinic receptor antagonist (mecamylamine injection). Donepezil (1 mg/kg) used as a reference drug. Distance to platform and time spent in escape platform quadrant were recorded and analyzed with Ethovision XT version 9.0 (Noldus, Wageningen, Netherlands). Results were statistically analyzed with oneway ANOVA. Results: Mecamylamine significantly increased the distance to platform and decreased the time spent in the escape platform quadrant compared to control group. Galangin 100, but not 50 mg/kg significantly decreased the distance to platform and increased the time spent in the escape platform quadrant compared to mecamylamine group comparable to donepezil 1 mg/kg. Conclusion: Galangin 100 g/kg may improve memory comparable to donepezil and nicotinic receptors may be involved in this effect.

Biography :

Fatma Sultan Kilic has completed her PhD from Anadolu University, Turkey. She has been working as an Academic Member and also contunuing her PhD at Faculty of Education. She has published more than 45 papers in reputed journals.

Email: fskilic@ogu.edu.tr