Journal of Clinical & Experimental Pharmacology

The reproductive toxicity of ZishenYutai pill on rats and offspring in perinatal period

8^th World Congress on Pharmacology and Toxicology

July 24-25, 2017 Melbourne, Australia

Li Zhou, Juan Jiang, Yang Yang, Da-wei Yan, Li Xu, Li-ming Chong and Zu-Yue Sun

Shanghai Institute of Planned Parenthood Research Hospital, China

Posters & Accepted Abstracts: Clin Exp Pharmacol

Abstract:

Objective: ZishenYutai Pill (ZYP) is one of the most commonly used Chinese medicines in prevention of early pregnancy loss due to threatened and recurrent miscarriage. Although it is widely used, its toxicity during perinatal period has not been well understood. Its main components include Radix Codonopsis, Radix Dipsaci, Polygoni multiflori, Atractylodes macrocephala, Morinda officinalis, Eucommia ulmoides, Semen cuscutae and Radix rehmanniae praeparata. In recent years, the research on ZYP has been increased year by year. Previous studies have shown that ZYP combined with phloroglucinol is significantly effective in the treatment of threatened abortion. Methods: Pregnant rats (F0) were exposed to 6 g/kg, 12 g/kg and 24 g/kg body weight/d of ZYP by intragastric administration from gestation day 15 (GD15) to through parturition and lactation up to weaning i.e., post-natal day 21 (PND21). Water and propylthiouracil (PTU, 15 mg/kg) were used as the negative control and positive control respectively. The mating was done between the treatment (ZYP or PTU) group and negative control group when the F1 pups were born on 63 days. Results: The reproductive capacity of F0 and F1 generation decreased significantly after PTU exposure (P<0.05), however the body weight and reproductive ability of F0, the physical development and feed consumption of F1 as well as the reproductive ability and survival rate of F2 rats were not significantly changed in the ZYP group compared with the negative control group (P>0.05). Conclusion: There was no statistically significant evidence of perinatal toxicity under ZYP exposure.

Biography :

Li Zhou has completed her PhD from Beijing Institute of Pharmacology and Toxicology and Postdoctoral studies from Chinese Academy of Medical Sciences. She is the Deputy Director of National Evaluation Centre for the Toxicology of Fertility Regulating Drug. She has published more than 40 papers in China and abroad reputed journals.

Email: zhoulijss@163.com