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The effects of Zataria multiflora extract on Dyrk1B gene expression in metabolic syndrome and coronary artery disease
7th International Conference and Exhibition on Cell and Gene Therapy
March 15-16, 2018 | London, UK
Reza Naderipour
Arsanjan university, Iran
Posters & Accepted Abstracts: J Stem Cell Res Ther
Abstract:
Introduction: Zataria multiflora, known as Avishan-e-Shirazi in Persian, is a wild plant that grows in Central and Southern Iran. In Iran, Zataria multiflora is used in traditional folk remedies for its antiseptic, pain-relieving and carminative. Cardiovascular disease (CVD) is the most common cause of death in developed countries and many developing countries. Metabolic syndrome (MS) is a collection of disorders that occur together and increase the risk of developing type 2 diabetes or cardiovascular diseases (stroke or heart disease). In addition, recent studies have shown Dyrk1b gene involved in metabolic syndrome. Methods: Mesenchymal cells were grown in Dulbecco�??s modified eagle medium (DMEM) supplemented with 10% fetal bovine serum, and 1% pen/strep. After differentiating of mesenchymal cells, cells were treated separately in the presence of Zataria multiflora extract. RNA extraction from mesenchymal cells was performed and Dyrk1b expression levels were examined by real-time PCR method. Results: Expression of Dyrk1b when subjected to differentiation, increased 4.34 fold (p value=0.0062). It was also seen that Dyrk1B expression in differentiated cell groups treated with Zataria (6 µg/ml: thyme 1, 12 µg/ml: thyme 2) decreased gene expression compared to differentiated cell group. Discussion: This study provides evidence that Zataria multiflora can reduce Dyrk1B expression and it may be used as an effective and safe therapy for treatment in MS patients.
Biography :
Reza Naderipour a MS student in Genetics. He has done research on Dyrk1B gene and medicine plants. He has worked in a genetic counseling center for a while.
Email:r.naderipour85@yahoo.com