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The effect of Zataria multiflora and its constituent, carvacrol, on tracheal responsiveness and lung pathology in guinea pig model of COPD
5th Asia Pacific Global Summit and Expo on Vaccines & Vaccination
July 27-29, 2015 Brisbane, Australia
Mohammad Hossien Boskabady*, Lila Gholami Mahtaj and Nima Mohamadian Roshan
Posters-Accepted Abstracts: J Vaccines Vaccin
Abstract:
Chronic obstructive pulmonary disease (COPD) is a progressive lung inflammation disease, mainly due to cigarette smoking. Anti-inflammatory property of Zataria multiflora (Z. multiflora) and its constituent, carvacrol was shown in various inflammatory disorders previously. Therefore, in present study, the effects of Zataria multiflora (Z. multiflora) and its constituent, carvacrol, in guinea pigs model of Chronic obstructive pulmonary disease (COPD) were examined. Animals were divided into; control, COPD, COPD + drinking water containing three concentrations of extract of Z. multiflora (0.4, 0.8 and 1.6 mg/ml), COPD + drinking water containing three concentrations of carvacrol (60, 120 and 240 ?g/ml) and COPD + dexamethasone (50 ?g/ml). COPD was induced by exposing animals to cigarette smoke for 3 months. Emphysema as a pathological change of the lung and tracheal responsiveness were measured (n=5 for control and COPD groups and n=6 for another groups). Tracheal responsiveness (p<0.05) and emphysema were significantly increased (p<0.001) in COPD compared to the control group. Tracheal responsiveness in COPD groups treated with two higher concentrations of the Z. multiflora and three concentrations of carvacrol, and emphysema in treated with highest concentration of Z. multiflora and carvacrol were significantly improved compared to COPD group. Studied parameters were also significantly improved in the treated group with dexamethasone compared to COPD animals (p<0.05 to p<0.01). The results indicated a preventive effect of Z. multiflora extract and its constituent, carvacrol on tracheal responsiveness and pathological changes of the lung.