Rajeshkumar Anbazhagan, Hsieh-Chih Tsai and Ru-Jong-Jeng
National Taiwan University of Science and Technology, Taiwan
National Taiwan University, Taiwan
Scientific Tracks Abstracts: Biol syst Open Access
In this paper, water soluble core shell molybdenum disulphide (MoS2) gadolinium complex was synthesized and used as in vivo MRI contrast agents. Briefly, monolayer MoS2 nanosheets were exfoliated with help of thioglycolic acid (TGA) as stabilizing agents by room temperature stirring followed by the sonication in water. Subsequently, luminescent MoS2 quantum dots with sustained fluorescence emission, which were fabricated through hydrothermal treatment of exfoliated MoS2 and could be utilized as cell biomarkers. These primary in vitro cell imaging results proved the biocompatibility of the nanomaterials, it could be used as in vivo imaging candidate in future. Therefore, we develop core-shell molybdenum disulfide and gadolinium complex, as an alternative in vivo MRI candidate. The synthesized core-shell contrast agents�?? exhibits enhanced paramagnetic property; compared to commercial gadolinium contrast agents core-shell MoS2 chelate has 4.5-times longer water proton spin-lattice relaxation time (T1); as well as lowered toxicity, extended blood circulation time, increased stability and desirable excretion characteristic. Transmission electron microscopy (TEM) proved core-shell nanoparticles 100 nm in size. These findings suggest that the synthesized nanomaterials possess high potential as a positive contrast agent for the enhancement of MRI imaging.
Rajeshkumar Anbazhagan has completed his Master’s degree from Annamalai University and studying PhD in National Taiwan University of Science and Technology, Taiwan. He has published 2 papers in reputed journals.
Email: arrajeshkumar6@gmail.com
