Synthesis and evaluation of anti-platelet aggregation activity of some novel n-substituted indole hydrazone derivatives
World Congress on Pharmacology
July 20-22, 2015 Brisbane, Australia

Nadia Kalhor1, Matin Mardani1, Marjan Esfahani Zadeh2, Farzad Kobarfard2 and Shohreh Mohebbi1

Posters-Accepted Abstracts: Clin Exp Pharmacol

Abstract:

Since thromboembolic disorders are one of the major cause of death worldwide and according to the anti-platelet activity of indole derivatives and hydrazone derivatives which have been reported in recent studies, a new series of indolehydrazone derivatives was designed and synthesized using indol-3-carbaldehyde as the lead compound and molecular hybridization approach. Derivatives 1 2 3 4 5 6 7 8 9 10 11 12 R CH3 C2H5 benzyl 2-F-benzyl 3-F-benzyl 4-F-benzyl 2-Br-benzyl 2-CN-benzyl 2-Cl-benzyl 2-CH3-benzyl 3-CH3-benzyl 4-CH3-benzyl The structure of synthesized compounds was confirmed by different spectral methods such as MASS, HNMR and IR spectroscopy. The in vitro anti-platelet activity of these compounds was evaluated using arachidonic acid (AA), adenosine diphosphate (ADP) and collagen as aggregation inducers. Based on the results, compounds (1b- 6b) showed considerable activity against arachidonic acid-induced platelet aggregation. Among them, compounds 1b and 2b were the most potent derivatives with IC50 comparable to that of indomethacin as standard drug. None of the compounds showed a promising response to either ADP or collagene induced platelet aggregation.