Shyh-Chyun Yang, Huang-Kai Peng Cherng-Chyi Tzeng and Jin-Ching Lee
Hepatitis C virus (HCV) infection is a main cause of chronic liver disease, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Th e objective of our research was to develop eff ective agents against viral replication. Herein, we have synthesized a series of anilinocoumarin derivatives. Based on a cell-based HCV replicon system, we observed that 3-(3?,4?,5?-trimethoxyanilin-1?-yl)methylaminocoumarin ( 3 ) exhibited anti-HCV activity with a 50% eff ective concentration (EC 50 ) value of 7.2 μM and a selective index (SI) value of 21. We concluded that the compound 3 possessed a potent activity against HCV replication and could provide as a new lead compound as anti- HCV inhibitors
Prof. Shyh-Chyun Yang has completed his Ph.D at the age of 31 years from Kaohsiung Medical University. He has published more than 43 papers in reputed journals.