Araceli Diaz Perales
Center for Plant Biotechnology and Genomics, Spain
Posters & Accepted Abstracts: J Allergy Ther
The study of cross reactivity in allergy is a key to both understanding the allergic response of many patients and providing them with a rational treatment. In the present study, protein microarrays and co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross reactivity between members of LTP family and could become a useful strategy to analyze other families of allergens.
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