Journal of Nanomedicine & Nanotechnology

Stimuli-responsive polyelectrolyte multilayer thin films for remote activated dual drug delivery

3^rd International Conference on Nanotek & Expo

December 02-04, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

S Anandhakumar

Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

We demonstrate a novel drug loading protocol in polyelectrolyte thin films to develop a transparent, dual drug loaded thin film platform for remotely activated drug delivery. The composite film was designed by alternate adsorption of poly(allylamine hydrochloride) (PAH) and poly(methacrylic acid) (PMA) on glass substrate followed with nanoparticle synthesis through polyol reduction method. The films showed a uniform distribution of spherical silver nanoparticles with an average diameter of 50 ? 20 nm, which could be increased to 80 ? 20 nm when the AgNO3 concentration increased from 25 to 50 mM. The porous and supramolecular structure of polyelectrolyte multilayer film was used to immobilize ciprofloxacin hydrochloride (CH) and bovine serum albumin (BSA) in the polymeric network of the film. The film undergoes morphological changes when exposed to internal and external triggers such as pH, ionic strength, laser light and ultrasound. When exposed to these triggers, the loaded films get ruptured and releases the loaded BSA and CH. The release of CH is faster than that of BSA due to their higher diffusion rate. Circular dichroism measurements confirmed that there was no significant change in the conformation of released BSA in comparison with native BSA. Applications envisioned for such drug-loaded films include drug and vaccine delivery through transdermal route, antimicrobial or anti-inflammatory coatings on implants and drug-releasing coatings for stents

Biography :

S. Anandhakumar has completed his Ph.D. from Indian Institute of Science (IISc), Bangalore in 2011 and continued as a postdoctoral fellow for few months in IISc. Then he joined as a Assistant Professor in SRM university in March 2012. He has published 6 papers in reputed international journals and written one book chapter. He has been serving as a reviewer in many journals.