Journal of Stem Cell Research & Therapy

Stem cell based strategies for whole kidney regeneration

6^th International Conference and Exhibition on Cell and Gene Therapy

March 27-28, 2017 Madrid, Spain

Miguel Guillermo Garber

Revitacell Clinic, Spain

Scientific Tracks Abstracts: J Stem Cell Res Ther

Abstract:

Chronic kidney diseases affect thousands of people worldwide and the final consequence is a renal failure (RF) becoming an extremely important public health issue, hemodialysis alleviates the situation by filtering the patient's blood, but it does not replace other kidney functions such as hormone release or homeostasis regulation. Transplantation of donor organs is the ultimate treatment for patients suffering from end-stage renal failure. Chronic kidney disease is a state of endothelial dysfunction, accelerated progression of atherosclerosis and high cardiovascular risk. As a consequence, cardiovascular disorders are the main cause of death in end-stage renal disease (ESRD). Actually, seeking for novel therapies, Kidney regeneration is a challenging but promising strategy aimed at reducing the progression to end-stage renal disease (ESRD) and improving the quality of life of patients with ESRD. Adult stem cells are multipotent stem cells that reside in various tissues, such as bone marrow and adipose tissue. Nowadays, there is growing evidence indicating that, under pathophysiological conditions, stem cells (SCs) derived from adipose tissue are able to migrate to the injured kidney, and they seem to play a role in glomerular and tubular regeneration. Moreover, adipose derivative stem cells can promote structural and functional repair, including hematopoietic stem cells and mesenchymal stem cells, which can also participate in the repair process by proliferation and differentiation into renal lineages. Mesenchymal SCs have been shown to decrease inflammation and enhance renal regeneration.

Biography :

Miguel Guillermo Garber has over 30 years of experience in Internal Medicine and Cardiology, with expertise in regenerative medicine, training and education, research, product development and senior management. He has more than 12 years of working experience with stem cells, including building and managing the stem cell evaluation, exploring and developing stem cell therapies for cardiomyopathies, osteoarthritis and regenerative medicine at Stem cell Therapeutics Department of American Medical Information Group and Clinica Quirurgica Quantum. He is currently serving as Medical Director of Revitacell Clinic and Clinical Director of Regenerative Medicine Madrid. He is also a Professor of Regenerative Medicine and Editor of scholarly journals.

Email: mggarber@gmail.com