Journal of Nanomedicine & Nanotechnology

Spironolactone-loaded SLN versus NLC: Physicochemical characteristics, stability and in vitro release

5^th International Conference on Nanotek & Expo

November 16-18, 2015 San Antonio, USA

H R Kelidari, M Saeedi, J Akbari and K Morteza-Semnani

Mazandaran University of Medical Sciences, Iran

Posters-Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

Spironolactoe (SP), a synthetic steroid diuretic is a poorly water-soluble drug with a low and variable oral bioavailability. Regarding the good solubility of SP in lipid materials, SP loaded solid lipid nanoparticles (SP-SLNs) and nanostructured lipid carrier (SPSLNs) were thus prepared in this work for accelerating dissolution of this drug. The SP loaded NLC with stearic acid (SA) as solid lipid and different oleic acid (OA) as liquid lipid content and SLN without OA were prepared by probe ultrasonication method. With increasing the percentage of OA from 0 to 30 wt% in SLN/NLC, the average size and zeta potential of nanoparticles fell down and entrapment efficiency (EE%) rose dramatically. The obtained micrograph particles showed pronounced spherical shape with smooth surface. Differential scanning calorimeter (DSC) measurements indicated that the presence of OA reduced the melting temperature and melting enthalpy of solid lipid in NLC structure. The results reflected good long-term stability of the nanoparticles and the measurements show that the particle size remains lower in NLC compare to SLN formulations, 6 months after production. Dissolution of SP-SLN and SP-NLC was about 5.1 and 7.2 times faster than raw drugs in 120 min respectively. These results indicated that the SP loaded NLC containing 70:30 solid lipid to liquid lipid ratio is a suitable carrier of SP with improved drug EE and steady drug release properties.

Biography :

Email: hamidreza.kelidari@yahoo.com