Journal of Clinical & Experimental Pharmacology

Potential nutritional and in vitro inhibitory effects on ?-glucosidase of sea hare (Dolabella auricularia)

Joint Meeting on International Conference on Pharmacology and Toxicology & 18^th International Conference on Medicinal and Pharmaceutical Chemistry

October 18-19, 2018 Dubai, UAE

Azrifitria Amiruddin, Benny Manullang and Sri Purwaningsih

Syarif Hidayatullah State Islamic University Jakarta, Indonesia

Scientific Tracks Abstracts: Clin Exp Pharmacol

Abstract:

Dolabella auricularia, also known as sea hare, is a marine gastropod that it found in the waters of Indo ??? Pacific. The aims of this research were to explore the potential of nutritional content of the species and in vitro anti-diabetic activity of sea hare extract. The composition of fatty acid was measured by gas chromatography, amino acids were measured by high performance liquid chromatography and mineral was measured by atomic absorption spectrophotometer. In vitro anti-diabetic activity of the sea hare extracts was evaluated by measuring their inhibitory effect on alpha-glucosidase level. The sea hare contained nine essential amino acids and six non-essential amino acids. Total saturated fatty acids was at 5.33% (g /100g), MUFA at 2.11% (g/ 100g), PUFA at 4.1% (g/100g). Calcium was at 68100 mg/kg, potassium at 10000 mg/kg, sodium at 8200 mg/kg, and carbohydrate at 1.52%. Sea hare ethyl acetate extract has in vitro anti-diabetic activity better than methanolic extract. The ethyl acetate extracts inhibited alpha-glocosidase activity in vitro, in a concentration dependent manner (IC50=25.76 mg/mL). The present study confirms that sea hare had a rich source of nutritional and their inhibitory effects on alpha-glucosidase.

Biography :

Azrifitria has completed her PhD at the Indonesia University School of Medicine. She is the Head of Pharmacy Department at Syarif Hidayatullah State slamic University Jakarta, Indonesia. She has published several papers in reputed journals and get some course at pharmacy field at Tokushima Bunry Japan.

E-mail: azrifitria@uinjkt.ac.id