Journal of Clinical & Experimental Pharmacology

Potential effect of the extract of Zataria Multiflora and its constituent, carvacrol, on lung pathology, total and differential WBC, histamine, ige and eosinophil peroxidase levels in sensitized guinea pigs

World Congress on Pharmacology

July 20-22, 2015 Brisbane, Australia

Mohammad Hossein Boskabady1, Abas Tabatabaee2 and Sediqeh Jalali3

Posters-Accepted Abstracts: Clin Exp Pharmacol

Abstract:

The effect of Zataria multiflora (Z. multiflora) and its main constituents, carvacrol (a phenolic compound), on lung inflammation of sensitized guinea pigs was examined. Sensitized guinea pigs to ovalbumin (OA) were given drinking water alone (group S), drinking water containing three concentrations of the extract (0.2, 0.4 and 0.8 mg/mL), three concentrations of carvacrol and dexamethasone (50 μg/mL), (n=6, for all groups). Lung pathology, total and differential white blood cell (WBC), serum levels of IgE and eosinophil peroxidase (EPO) were evaluated. All pathological indices, serum IgE and EPO levels and total and differential WBC except lymphocytes in group S showed significant increase but lymphocyte was decreased compared to the control group (p<0.05 to p<0.001). Dexamethasone, all concentrations of the extract and carvacrol treatment caused significant improvement in all parameters compared to group S (p<0.05 to p<0.001). The effect of a high concentration of the extract and carvacrol was higher compared to dexamethasone in most parameters (p<0.05 to 0.001). These results showed a preventive effect of the extract of Z. multiflora and its constituent, carvacrol, on lung inflammation of sensitized guinea pigs. The effect of the plant is perhaps due to its constituent, carvacrol.