Journal of Vaccines & Vaccination

Pilot prospective multicentric case control study of severe pneumonia in children under fi ve years of age

International Conference & Exhibition on Vaccines & Vaccination

22-24 Nov 2011 Philadelphia Airport Marriott, USA

Gl�ucia Paranhos-Baccal�

Scientific Tracks Abstracts: J Vaccines Vaccin

Abstract:

Pneumonia is one of the leading causes of child mortality in developing countries accounting for an estimated 2 million deaths annually. Pneumonia can have a viral or bacterial origin; however, the etiological cause of pneumonia is diffi cult to diagnose. Since 2008, the Emerging Pathogens Laboratory of the Fondation M�rieux has been conducting a research program on the development of sensitive molecular assays for the identifi cation, the typing, and the characterization of pathogens responsible for pneumonia. Th e principal objective of the pilot multicentric study is to identify the viral and bacterial agents associated with severe pneumonia in hospitalized children less than fi ve years of age in developing countries and to determine the etiological distribution and involvement in the onset of pneumonia. Th e secondary objectives are: To study the co-infection viral/bacterial co-infection and if it constitutes a risk factor in the severity of the disease; To establish a correlation between the type of pathogens identifi ed (bacterial or viral) and the biomarkers: C reactive protein (CRP) and Procalcitonin (PCT); and To identify the serotypes of Streptococcus pneumoniae in nasopharyngeal and blood samples. Th is is a 12 months pilot prospective multicentric case-control study carried out in 9 countries: Brazil, Cambodia, China, Haiti, Lebanon, Madagascar, Mali, Mongolia, Paraguay; one participant center per country. Total study sample size is of 900 cases and 900 controls; respectively of 100 cases and 100 controls from each participant country. Th e study start in 2010 and the relevance and impact of this study will be presented before or aft er pneumococcal vaccine introduction programs.

Biography :

Gl?ucia Paranhos-Baccal? is the Research Director at the Emerging Pathogens Laboratory (LPE) in Lyon of Fondation M?rieux. Gl?ucia Paranhos-Baccal? has completed his Ph.D at the age of 26 years from S?o Paulo University in Brazil and postdoctoral studies from Pasteur Institute in Paris. She worked as Assistant Professor at the Medicine School, Sao Paulo University, Brazil for the Tropical Medicine Department. She joined bioM?rieux in 1990. She has published more than 60 papers in reputed journals and serving as an editorial board member of repute. Dr. Paranhos-Baccal?s research interests centered on molecular and cellular biology and on biochemistry of proteins to create tools for diagnostic and therapeutic approaches