Journal of Liver

New advances in approaching of the alteration of Intrahepatic microcirculation in cirrhotic livers

World Congress on Hepatitis

July 20-22, 2015 Orlando, Florida, USA

Ying-Ying Yang

Posters-Accepted Abstracts: J Liver

Abstract:

From a hemodynamic point of view, the hepatic vascular resistance and portal inflow determine the level of portal pressure. Factors that determine the hepatic vascular resistance include both structural and dynamic components. Among the structural components are histological characteristics such as steatosis, fibrosis and regeneration nodules and neoangiogenesis. Dynamic structures include cells with contractile properties such as hepatocytes, hepatic stellate cells, sinusoidal endothelial cells and Kupffer cells. The contributions of the interactions between four cells in cirrhotic livers resulted in hepatic endothelial dysfunction, hepatic microcirculatory dysfunction, hepatic venous dys-regulation, hepatic fibrogenesis and subsequently increased intrahepatic resistance and portal hypertension in cirrhosis. The pathogenic mechanisms triggering the associated abnormalities in hepatic microcirculations including persistent endotoxemia, increased hepatic oxidative stress, activated endocannabinoids substances, pathogenic sinusoidal remodeling and hypo-perfusion in cirrhotic livers. Cumulative data suggested various therapeutic strategies targeting on the hepatic microcirculation effectively improvement of the systemic abnormalities of cirrhosis. Accordingly, the mechanistic and therapeutic approaches focusing on the disarrangement of hepatic microcirculation will introduce in this article.