Pharmaceutica Analytica Acta

Microbubbles formulated with lipid nanocapsules for a better stabilization

8^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 07-09, 2016 Madrid, Spain

Mouzouvi Celia R A, Umerska Anita, Fouchet Florian, Bigot Andre and Saulnier Patrick

INSERM, France
Universite dAbomey-Calavi, Benin

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Microbubbles combined with ultrasounds have showed important effect on drugs and genes delivery. Indeed, these nanoscale particles filled with gas are able to oscillate in the presence of ultrasonic waves. Thus, the drug concentration at specific area is increased, improving their therapeutic effects and reducing adverse effects. Despite of that therapeutical advance, small bubbles stabilization remains a big challenge because of their inherent important Laplace pressures. In this study, we proposed to use well defined colloidal particles called Lipid Nano Capsules (LNCs) to stabilize air bubbles and to investigate on their behavior under ultrasounds using sodium fusidate as a tracer. Microbbubbles were prepared by modified agitation method. Sodium fusidate were incorporated by incubation. The pharmaceutical active triggering release was performed for the sample against a control in the PSB (phosphate solution buffer) using the instrument of Sonidel Limited SP 100. The size distribution of microbubbles formulated was in the range 0.6-2 μm with an average size of 1.5±0.56 (μm). The encapsulate rate for the bubbles, was 31%. The drug quantity released was 7.3% against 8.3% for the control. In conclusion, small bubbles can be stabilized by the LNCs allowing them to be charged in drug. The drug encapsulation efficiency and the drug release rate were acceptable because they exceed the minimum inhibitory concentration (IMC) of sodium fusidate. Furthermore, the sodium fusidate loadedmicrobubbles efficacy on the bacterial culture could be evaluated.

Biography :

Email: rosedescience@yahoo.fr