Lipid derived amphiphilic nano-carriers
5th International Conference on Nanotek & Expo
November 16-18, 2015 San Antonio, USA

Aman Ullah

University of Alberta, Canada

Keynote: J Nanomed Nanotechnol

Abstract:

Amphiphilic block copolymers and ABA type PEG-Lipid conjugated macromolecules have been synthesized using microwave-assisted reversible addition-fragmentation chain transfer (RAFT) polymerization and the copper-catalyzed azide-alkyne cyclo addition commonly termed as �??click chemistry�?� respectively. Characterization of the block copolymers and conjugates has been carried out with the help of 1H-NMR, FTIR and GPC. These copolymers and conjugates were evaluated for the encapsulation and release of drug. Carbamazepine, an anticonvulsant drug with poor water solubility was selected to be a hydrophobic drug model in the study. The micellization, drug encapsulation and release behavior of macromolecules was investigated by dynamic light scattering (DLS), transmission electron microscope (TEM) and fluorescence spectroscopy. From the results, it has been concluded that the nanoparticles had different average sizes due to different ratio of hydrophilic contents in the block or conjugate backbone. The particle size and structure could be altered by changing the ratio of hydrophilic and hydrophobic contents. The in vitro drug encapsulations highlighted that all the drug-loaded micelles had spherical or near-spherical morphology. In vitro drug release study showed the controlled release of hydrophobic drug over a period of max. 50 hours. The results indicate that there is great potential of renewable lipid-based micelle nanoparticles to be used as hydrophobic drug carriers.

Biography :

Dr. Aman Ullah received his PhD (with distinction) in Chemical Sciences and Technologies in 2010 at the University of Genova, Italy by working together at Southern Methodist University, USA. He is currently working as an Assistant Professor at the Department of Agricultural, Food and Nutritional Science, University of Alberta. He has published more than 20 papers in reputed journals. Aman was named a Canadian Rising Star in Global Health by Grand Challenges Canada in 2012.

Email: ullah2@ualberta.ca