Journal of Bacteriology & Parasitology

In vivo antimalarial evaluation of novel 4-amino quinazoline derivatives

International Congress on Bacteriology & Infectious Diseases

November 20-22, 2013 DoubleTree by Hilton Baltimore-BWI Airport, MD, USA

Frezer Abiy Assefa

Posters: J Bacteriol Parasitol

Abstract:

Malaria is a deadly parasitic infectious disease affecting billions of people around the world. A wide variety of quinazolines displayed potential antimalarial activities. Based on this, fifteen novel 4-aminoquinazoline derivatives were synthesized and tested for their in vivo antimalarial activities. The compounds were prepared using cyclization and condensation reactions. The structure of the synthesized compounds were verified using elemental microanalysis, IR, 1H NMR and 13C NMR spectral techniques. The in vivo antimalarial activities of the synthesized compounds were investigated using Swiss albino mice infected with Plasmodium berghi ANKA strain. All the synthesized compounds displayed significant antimalarial activities with percent suppression of 57.5-87.3 as compared to the control group (P>0.05). Among the synthesized compounds II, V, VIII and X showed promising antimalarial activities with percent suppression of 87.3, 84.6, 01.2 and 79.8 respectively which indicate 4-aminoquinazolines are fruitful matrixes for the development of antimalarial agents. In addition, the acute toxicity test indicated that these compounds are free of any inherent acute toxicity symptoms.

Biography :

Frezer Abiy Assefa has completed her B.Sc. degree in Chemistry and M.Sc. degree in Medicinal Chemistry from University of Gondar and Addis Ababa University School of Pharmacy respectively. She has served as a coordinator of research and community service at faculty level since 2012. In addition, she has submitted two research articles for peer review journal.