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Extemporaneous compounding for peadiatric dosage forms - Critical issue in clinical setting
10th World Congress on Bioavailability and Bioequivalence
April 08-09, 2019 Abu Dhabi, UAE

Heyam Saad Ali

Dubai Pharmacy College, UAE

Posters & Accepted Abstracts: J Bioequiv Availab

Abstract:

The issue of extemporaneous preparation in clinical settings is facing critical challenges in manipulating commercial medicines. The data and information for adjusting the accurate dose, over dose, and toxicity for pediatric use is lacking. Moreover, evaluation and stability of these preparations for pediatric population, need specialized trained and knowledgeable pharmacists to develop safety, stable and effective formulations. Furthermore, intensified compounding courses, workshops for the pharmacists is not been emphasized by authorities especially developed countries. The physiology, absorption, metabolism and pharmacodynamics in children are different from adult. Therefore, compounding of pediatric extemporaneous preparations from adult medicines is hazardous issue. Pharmacists may face with ethical and legal actions, problems and critical consequences from low therapeutic outcomes. Selection of the appropriate additives and the appropriate dosage form to dispense the prescribed dose is crucial, it needs expert consultation and proper guidance. Therefore, this piece of article focuses in proper selection of appropriate excipients, dosage forms according to pediatric ages.omplete knowledge and information regarding the pediatric physiology, pharmacokinetics and pharmacodynamics is available in WHO guidance [2007 First line list].Regarding the selection of the dosage and route of administration should be based on care givers convenience in admiration which enhance their adherence and compliance.Therefore, acceptability taste, odor the tools used for dose measurements, should be based on selection of safe, stable and compatible excipients in terms of pediatric age and disease status and it is provided in FDA site Generally Recognized as Safe list [GRAS], (SCOGS) Database.

Biography :

Heyam S. Ali is a Professor in Dubai Pharmacy College, Prof. Heyam Saad Ali has completed her PhD from Bradford University, UK. She is Head of Pharmaceutics Department, Dubai Pharmacy College, UAE. She has teaching and research experience of about 25 years. She has published more than 44 papers in reputed journals and has been serving as an editorial board member of several pharmaceutical Journals.

E-mail: heyam@dpc.edu