Nabiouni M, Hosseini S and Karimzadeh L
Kharazmi University, Iran
Posters-Accepted Abstracts: Nat Prod Chem Res
Background: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder among women of reproductive age which affects 5 to 6 percent of women, PCOS disorders characterized by an ovulation, hyperandrogenism, insulin resistance and the risk of metabolic syndrome is characterized increases. According to anti-inflammatory, antioxidant and hypoglycemic effects of nettle extracts, this therapeutic effect on Polycystic Ovary Syndrome was studied. Materials & Methods: Wistar adult rats were selected and divided into control and poly cystic induced by estradiol valerate. The group PCOS 2 mg/kg subcutaneously injected estradiol valerate after 60 days and confirmed polycystic, the group injected intraperitoneally on day 21 of the nettle extract doses (50, 150, 250, 350, 450 mg/kg). After 21 days, the mice were killed; blood samples and ovaries were collected to evaluate the histologic and serologic parameters. Data was analyzed using ANOVA one-way and p<0.05 was considered statistically significant. Results: Genesis numerous cysts increasing the thickness of theca layer and reduce the corpus luteum was observed in PCOS samples, while the number and size of cysts in the ovaries of the treated group and the granulosa layer thickness decreases and increased the number of luteinizing and follicle antral. Reviews of serologic parameters are also a significant in improvement in serum levels of glucose, cholesterol and triglycerides and insulin were observed and modify sex hormones. Nettle extract was also another treatment results. Conclusions: The results show that the nettle extract improves morphological and histological poly cystic ovaries and improve the complications of metabolic syndrome and sex hormones is modified.
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