Effect of polyethylene glycol 4000 in a thermosensitive and bioadhesive gel for postoperative pain treatment
8th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems
March 07-09, 2016 Madrid, Spain

Diana Arbelaez-Camargo, Isaac Nofrerias, Marc Sune, Josep Sune-Negre, Expert; Encarna Garcia-Montoya and Pilar Perez-Lozano

University of Barcelona, Spain

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

During the first 24 �?? 48 hours after an abdominal surgery, the continuous administration of local anaesthetics (LA) and concominats in the optimal anatomical space, minimizes the systemic side effects and improves postoperative pain management. With this aim, a thermosenstive gel was formulated using poloxamer 407 (P407) as the main polymer with a concentration of 12.5%; hidroxypropylmethylcellulose (HPMC) as bioadhesive agent and polyvinylpyrrolidone (PVP) to modify and adjust the gelation temperature. As active pharmaceutical ingredients, lidocaine hydrochloride (LC) and dexamethasone sodium phosphate (DSP) were used for their synergistic analgesic effect and set at 2% and 0.4% respectively. Polyethylene glycol 4000 (PEG 4000) was added to improve the bioadhesive profile of the formulation due to the physiological characteristics of the peritoneum and other non-mucosal tissues. The adition of PEG 4000 to the formulation, caused a change in the thermosensitive character of the gel, therefore, no gelation was observed when increasing the temperature. At the same time, there was a decrease in the viscosity when increasing the temperature (p-value ) and the PEG 4000 concentration (p-value ), results that confirmed a change in the properties of the gel. As security parameters to prevent local irritation, pain or endothelial damage, osmolality and pH were studied. Osmolality was affected by the addition of PEG 4000 (p-value ) but did not exceed the expected values (�?� 400 mOsm/Kg), in the other hand, the pH was not affected by PEG 4000 (p-value), it remained between aceptable values that provide API`s stability.

Biography :

Diana Arbelaez-Camargo is a second year PhD student with one publication in the International Journal of Pharmaceutics and an accepted poster presentation at the 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology of Glasgow on 5th of April, 2016 in the controlled drug delivery session. She is also working as Pharmaceutical Development Technician in OPKO Lab Europe, S.L.

Email: diancrayolina@gmail.com