Masoud Afshari
Tehran University of Medical Sciences, Iran
Posters & Accepted Abstracts: J Diabetes Metab
Introduction: Diabetes is a common metabolic disease that has different effects on the body. Ferulic acid has a potential antioxidant effects and also has anti diabetic effects. The aim of this study was to evaluate the oral administration of ferulic acid on learning and memory impairment induced by diabetes. Methods: We used STZ to induce diabetes in male Wistar rats. Rats divided randomly into four groups for assement of memory and cognitive functions after 4 weeks by using Morris water maze, Y-maze and shuttle box, and also their brains were removed and investigated for oxidative stress, actyl choline esterase concentration and nissl staining in hippocampus. Results: Ferulic acid treatment can improve performance in MWM, Y-maze and passive avoidance test. This treatment also decreases oxidative damage and significantly decreases choline esterase activity. Increase in neural density (CA1) in treatment groups measured in 16 weeks after induction of diabetes. Conclusion: Taken together, our data suggests that Ferulic acid treatment can improve cognitive and learning ability in diabetic rats by reducing oxidative damage, choline esterase activity and increase in neural density in diabetic rats.
Email: m-afshari@razi.tums.ac.ir
