Rodriguez Lopez L, , Cruz J M, Moldes A B and Waters L
University of Vigo, Lagoas-Marcosende Campus, Spain
University of Huddersfield, UK
Scientific Tracks Abstracts: J Microb Biochem Technol
Nowadays, one of the most important challenges in the pharmaceutical industry is to find additives for formulations which improve the permeation and solubility of drugs. Usually, because of their solubilising and emulsifying properties, it is common to use surfactants in ointments and creams. However, some allergies and adverse effects have been associated with these kinds of substances. In this sense, the study of biosurfactants as an alternative to synthetic surfactants is playing a more important role. Biosurfactants are surface-active compounds, composed of biomolecules, with some advantages in comparison with their chemical counterparts, such as biodegradability or low toxicity. For this reason, the aim of this work was to study the effect of a biosurfactant extract, obtained from a corn-milling industry stream, in drug permeation through polydimethylsiloxane (PDMS). This polymer was chosen as a skin mimic, due to its good correlation with an in vivo situation in a case whereby the penetrant lipophilicity was the prime determinant of compound permeation. During this study, the permeation of five drugs in the presence of biosurfactant at different concentrations were determined, in comparison with a control without the biosurfactant extract. The results obtained have shown the capacity of this biosurfactant extract to maintain or improve drug permeation through PDMS. This is a promising approach in comparison with the results obtaining with chemical surfactants like sodium dodecyl sulfate (SDS) in the same conditions. Recent Publications 1. Savjani K T, Gajjar A K and Savjani J K (2012) Drug solubility: Importance and enhancement techniques. ISRN Pharmaceutics 2012:1-10. 2. Kato K, Igawa K, Nishizawa A, Takayama K and Yokozeki H (2016) Allergic contact dermatitis induced by the anionic surfactant, sodium N-methyl-N-(1-oxododecyl)-beta-alaninate, contained in a daily-use shampoo. Journal of European Academy of Dermatology and Venereology 30:e123-e124. 3. Saha P and Rao K V B (2017) Biosurfactants-a current perspective on production and applications. Nature Environment and Pollution Technology 16:181-188. 4. Moss G P, Gullick D R and Wilkinson S C (2015) Predictive methods in percutaneous absorption. ISBN 978-3-66247371-9.
Rodriguez López L is a PhD student in University of Vigo. She has completed her Chemistry Degree in 2014, and her Master’s degree in Advanced Biotechnology in 2016, both in University of Vigo. She has co-authored six articles in JCR journals. Moreover, she has collaborated for three months in the Department of Pharmacy in University of Huddersfield, United Kingdom, where she started the study and presented under the supervision of Dr. L. Waters.