Oral Health and Dental Management

Comparative evaluation of antifungal activity of Melaleuca oil and fluconazole when incorporated in tissue conditioner - An in vitro study

5^th American Dental Congress

October 05-07, 2015 Philadelphia, USA

Veena Hegde

Manipal College of Dental Sciences, India

Posters-Accepted Abstracts: Oral Health Dent Manag

Abstract:

Purpose: This study sought to compare in-vitro, the antifungal activity of Melaleuca alternifolia oil and fluconazole mixed with a tissue conditioner. Methodology: By testing several concentrations of fluconazole and Melaleuca oil in visco-gel, minimum most effective concentration of each antifungal agent against Candida albicans was determined. The parameter used to measure the antifungal activity was mean inhibition diameter and data were analyzed statistically for significance of findings. Result: The minimum most effective concentrations of melaleuca oil in viscogel and fluconazole were 30% w/w and 5% w/w respectively. 30% w/w melaleuca oil was found to be most effective (P<0.001) and superior to 5% fluconazole in viscogel as it retained substantial anti-fungal activity (mean inhibition diameter) even on day 7 when Fluconazole had lost its anti-fungal effect completely as evidenced by re-growth of Candida albicans by day 7. Conclusion: 30% melaleuca oil in tissue- conditioner viscogel is superior to 5% fluconazole in viscogel as anti-fungal agent. Though both showed comparable anti-fungal activity at 24 hours against Candida albicans, yet fluconazole had completely lost it by day 7 whereas melaleuca oil had retained its anti-fungal action substantially.

Biography :

Veena Hegde is Professor in Prosthodontics and crown and bridge at Manipal College of Dental Sciences.

Email: drveenahebbar@yahoo.com