Pharmaceutica Analytica Acta

Coated prolonged release minitablets with Carbamazepine

8^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 07-09, 2016 Madrid, Spain

Maja Szczepanska, Magdalena Czajkowska, Hanna Kotlowska, Benedikt Haupler and Malgorzata Sznitowska

University of Gdansk, Poland
Ludwig-Maximillians-University, Germany

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Minitablets (MT) are innovative solid oral forms designed especially for pediatric and geriatric patients with swallowing problems. MT (diameter 1-3 mm) are regarded as a multiple unit dosage forms, same as granules or pellets, where the dose is administered as a variable number of subunits. Multiple unit dosage with controlled release carry lower risk of uncontroled burst release of the drug. Minitablets are alternative for pellets because of their ease of preparation. Due to the defined sizes, weight and smooth surface minitablets are produced in a more reproducible and continuous way. The aim of the study was to develop minitablets (2.5 mm cores) with prolonged release, where carbamazepine (CBZ) was a model drug. Modified release was achieved by fluid bed coating. Two series of minitablets containing 25% of CBZ were prepared; by direct compression (MT-DC) or by compression after granulation (MT-GR). Rotary tablet press (Erweka RTP-D8, Germany) was used. MT were coated in fluid bed system (Aircoater 025, Innojet) using a mixture of aqueous dispersions of Eudragit RL and RS polymers at various ratios. The dissolution rate was modified by film thickness and addition of pore forming polymers. Prolonged release of CBZ was achieved for MT-GR with 1:1 Eudragit RL/ RS ratio (50 μm film thickness), whereas for MT-DC coated with 1:9 Eudragit RL/RS ratio (30 μm film thickness) drug release rate was found optimal. The drug release profiles of MT complied with the USP requirements for prolonged release tablets. Addition of the pore forming polymers (hypromellose, polyvidone) allowed to eliminate the initial delay in the active substance release.

Biography :

Maja Szczepa�?ska is a first year PhD student at the Medical University of Gda�?sk, Poland. She completed her Master’s degree in Pharmaceutical Sciences in 2014. She is working on her PhD thesis at the technology of minitablets. The aim of her work is to optimize the coating process of minitablets and develop a method for testing the release rate from coated minitablets.

Email: maja.szczepanska123@gmail.com