Journal of Vaccines & Vaccination

Association of high risk human papilloma virus genotypes with oral squamous cell carcinoma among Pakistani patients

9^th Global Summit and Expo on Vaccines & Vaccination

November 30-December 02, 2015 San Francisco, USA

Zil-e-Rubab

Ziauddin University, Pakistan

Posters-Accepted Abstracts: J Vaccines & Vaccin

Abstract:

In Pakistan, oropharyngeal cancer is the second leading malignancy attributed to the extensive use of smokeless tobacco products. In many studies, the high risk genotypes of HPV are proven to play a key role in Oral Squamous Cell Carcinoma (OSCC). There is a considerable diversity in the epidemiology of high risk HPV genotypes in different countries. The objective of this study was to find out the association between high-risk HPV genotype in oral rinse of patients with OSCC and pre malignant oral lesions. In this case-control study, 200 samples of oral rinse were analyzed by PCR. A significant association between HPV and OSCC was found (OR=3.14, 95% CI=1.6750-5.8969, P value=0.0004). There was positive association between presence of both HPV 16/18 and OSCC but it was not significant possibly due to small sample size (OR=3.2381, 95% CI=0.8208-12.7752, P value=0.0934). As a result of these findings, HPV and predominant genotypes 16 and 18 may be associated with the development of OSCC in Pakistan.

Biography :

Email: zile_rubab@hotmail.com