Sang Hee Shim, Wei Li, Soonok Kim and Young-Sang Koh
Duksung Women�??s University, South Korea
Korea Institute of Oriental Medicine, South Korea
National Institute of Biological Resources, South Korea
Jeju National University, South Korea
Posters & Accepted Abstracts: Nat Prod Chem Res
Six new isochroman derivatives (annulohypoxylomans A�??C, 1�??3; annulohypoxylomanols A and B, 6 and 7; and annulohypoxyloside, 8), an isocoumarin (annulohypoxylomarin A, 4), and an azaphilone derivative (xylariphilone, 5) were isolated from an ethyl acetate extract derived from cultures of the endophytic fungus JS540 found in the leaves of Zizania caduciflora. The JS540 strain was identified as Annulohypoxylon truncatum. The structures of the isolated compounds were elucidated by one- and two-dimensional nuclear magnetic resonance and mass spectrometry, and by comparison with related compounds from the literature. The anti-inflammatory activities of the isolated compounds were evaluated in Lipo Polysaccharide (LPS)-stimulated bone marrow-derived dendritic cells. Xylariphilone (5) exhibited significant inhibitory effects on LPS-induced interleukin (IL)-6, IL-12 p40, and Tumor Necrosis Factor (TNF)-α production with IC50 values of 5.3, 19.4, and 37.6 μM, respectively.
Sang Hee Shim has her expertise in Natural Products Chemistry. She has done her studies on bioactive secondary metabolites from medicinal plants and their associated micro-biomes including endophytes. She investigated a lot of bioactive secondary metabolites from halophyte-derived microbial cultures and is trying to elucidate interactions between plants and their endophytes.
Email: sangheeshim@duksung.ac.kr
