Journal of Clinical & Experimental Pharmacology

Anti-diabetic effects of water extract of Dendropanax morbifera leaves in db/db mice

8^th World Congress on Pharmacology and Toxicology

July 24-25, 2017 Melbourne, Australia

Se-Young Choung, Jae-Hyuk Byun and Myeong-Gang Heo

Kyung Hee University, South Korea

Posters & Accepted Abstracts: Clin Exp Pharmacol

Abstract:

In the present study, we investigate the effect of the water extract of Dendropanax morbifera leaves (DLE) on anti-diabetic activity in the diabetic db/db mice. 6-week-old male db/m+ and 5 groups of db/db mice were treated with metformin or DLE for 6 weeks, db/m+ group (normal), db/db group (control), metformin group (positive control, 200 mg/kg) and the DLE groups (50, 100, 200 mg/kg). The oral administration of DLE or metformin significantly lowered serum glucose, insulin, HbA1c, c-peptide and serum lipid levels (TG, TC) in db/db mice. Additionally, the safety of 6 weeks administration of DLE was confirmed when considering that the level of AST, ALT and BUN in serum were within the normal range. Histological analysis with H&E staining indicated that DLE treated group showed the higher number of hepatic nucleus compared to the db/db group. To understand the molecular mechanism of DLE, the expression level of genes associated with diabetes was measured in liver and muscle tissue. The expression of glucose metabolism and transport genes (glucokinase, glucose transporter type-2 and 4) and glycogen synthase of db/db mice was increased by DLE. On the other hand, DLE treatment resulted in decreased expression level of gluconeogenesis related genes such as glucose-6-phosphatase, phosphoenolpyruvate and carboxykinase. These results suggest that DLE may have the possibility to ameliorate type-2 diabetes. Therefore, DLE could be extensively used as a functional food for mitigating type-2 diabetes.

Biography :

Se-Young Choung has completed his PhD from Tokyo University, Graduate School of Pharmacy. He is the Professor of Kyung Hee University College of Pharmacy and the President of Korean Accreditation Council for Pharmacy Education. He has published more than 30 papers in reputed journals and has been serving as an Editorial Board Member of repute.

Email: sychoung@khu.ac.kr