Bhavesh C Variya and Snehal S Patel
Nirma University, India
Posters-Accepted Abstracts: J Diabetes Metab
Peroxisome proliferator-activated receptor-γ (PPAR-γ) plays a key role in insulin sensitivity and is promising target to improve insulin sensitivity. From the ancient time, Emblica officinalis has been used in Ayurveda for the management of various ailments, including diabetes, however the mechanism still remains to be elucidated. In the present study, we showed that 42 days treatment with fruit juice of E. officinalis (2 ml/kg/day, p.o.) and isolated active moiety, gallic acid (100 mg/kg/day, p.o.), can produce decrease in blood glucose level as well as body weight in db/db mice. The treatment showed a reduced serum insulin level with decreased AUCglucose in OGTT test. The triglyceride and %HbA1c levels were also found to be significantly abridged in treated animals as compared to normal control. Furthermore, gallic acid showed significant adipogenesis in 3T3-L1 with up-regulation of PPAR-γ and glucose transporter-4 (GLUT-4). From our data, we demonstrated that E. officinalis and gallic acid improves glucose tolerance and shows anti-diabetic activity through up-regulation of PPAR-γ and GLUT-4 and can be a good lead for development of newer antidiabetic drugs having better efficacy with minimal adverse effects.
Email: bcvariya@gmail.com
