Journal of Vaccines & Vaccination

A vaccine pipeline: Using phage display for identification of immunogenic proteins and generation of human antibodies for diagnostics and therapy

4^th International Conference on Vaccines & Vaccination

September 24-26, 2014 Valencia Convention Centre, Spain

Michael Hust

Scientific Tracks Abstracts: J Vaccines Vaccin

Abstract:

T he identification of new immunogenic proteins of pathogens is a prerequisite for development of vaccines and diagnostic assays. We are using phage display to identify novel antigens from bacterial genome libraries. We also developed an antibody generation pipeline. The combination of both phage display based technologies led to a ?vaccine development pipeline?. Here, the technology will be described and examples for the identification of immunogenic proteins of Mycoplasma species and Salmonella Typhimurium as well as examples from our antibody generation and engineering pipeline for pathogens and toxins (botulinum toxins, Venezuelan equine encephalitis virus) will be given.

Biography :

Michael Hust studied biology at the Carl von Ossietzky Universit?t in Oldenburg, Germany, from 1993-1999. He got his PhD at the Leibniz Universit?t in Hannover, Germany, in 2002. Since end of 2002, he is working as group leader at the Technische Universit?t Braunschweig, Germany, in the Department of Biotechnology. In 2011 he finished his professorial dissertation (Habilitation, venia legendi for Biotechnology) and was appointed as Privatdozent (PD). He has published more than 70 articles (including book chapters and reviews) on antibody engineering and phage display. He cofounded the mAb-Factory GmbH in 2007 and the Yumab GmbH in 2012. He is working on the development of human and human-like antibodies for diagnostics and therapy. Another field of work is the identification of immunogenic proteins of pathogens using phage display