Editorial - (2021) Volume 10, Issue 7

Fungal Infection and its Role in Cystic Fibrosis
Luis Jun*
 
Department of Microbiology and Immunology, Muhimbili University of Health Sciences, Dar es Salaam, Tanzania
 
*Correspondence: Luis Jun, Department of Microbiology and Immunology, Muhimbili University of Health Sciences, Dar es Salaam, Tanzania, Email:

Received: 07-Jul-2021 Published: 29-Jul-2021, DOI: 10.35248/2327-5073.21.10.e211

Editorial Note

Infections caused by fungi are frequent in many parts of the natural world. Fungal infections in humans occur when an invasive fungus takes over an area of the body and overwhelms the immune system. Fungi can live in a variety of environments, including the air, soil, water, and plants. Some fungus can also be found naturally in the human body. There are beneficial and toxic funguses, just like there are beneficial and hazardous bacteria. Hazardous fungus can be hard to eliminate after they have infiltrated the body since they can survive in the environment and re-infect the person who is trying to recover. Common symptoms of fungal infections are itching, as well as skin changes such as redness, cracking, or peeling. Some fungus reproduces by dispersing microscopic spores into the air. The spores can be inhaled or they can land on you. As a result, many fungal infections start in the lungs or on the skin. If you have a weaker immune system or are on antibiotics, you are more susceptible to contract a fungal infection. Fungi are notoriously tough to eradicate. You can apply medicine directly to the diseased region for skin and nail infections. Serious infections can also be treated with antifungal medications taken orally.

Airway infections are a major cause of illness and mortality in people with Cystic Fibrosis (CF). The CF microbiological landscape has clearly changed in the last two decades, with a surge in the recovery of filamentous fungi, the most common of which are Aspergillus fumigatus and Scedosporium species. The cystic fibrosis community has responded by raising many concerns about the clinical implications of Aspergillus fumigatus and other fungi identified in lung cultures in the absence of an allergic host response. Mucociliary clearance problems are linked to local immunological problems in people with cystic fibrosis. In addition, long-term antibiotic medication and corticosteroid treatment may promote fungal development. Although the clinical significance of fungal airway colonisation is still debated, As with allergic bronchopulmonary aspergillosis, the most frequent fungal disease in the context of CF, involving a Th2- driven immune response to Aspergillus species, filamentous fungi may contribute to the local inflammatory response and hence to the progressive worsening of lung function. Many various procedures for diagnosing cystic fibrosis exist, including neonatal screening, sweat testing, and genetic testing. Fungal epidemiology in the Cystic Fibrosis population has been recorded in numerous parts of the world, and the most frequent moulds in the CF respiratory tract are Aspergillus fumigatus and Scedosporium species. Cystic fibrosis has no known treatment. Antibiotics are used to treat lung infections, and they can be given intravenously, breathed, or taken orally. The antibiotic azithromycin is sometimes used for a long time. Salbutamol and hypertonic saline inhalation may also be beneficial. If your lung function continues to deteriorate, lung transplantation may be an option. Replacement of pancreatic enzymes and fat-soluble vitamin supplements are critical, especially in children. Techniques for clearing the airways, such as chest physiotherapy, are beneficial in the short term, but their long-term implications are unknown.

Citation: Jun L (2021) Fungal Infection and its Role in Cystic Fibrosis. Clin Microbiol. 10:e21

Copyright: © 2021 Jun L. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.