Professor, Director of Research Strategy and Development School of Veterinary Science
University of Queensland, Australia
Michael k Holland is Professor (Level E)-Professor of Animal Biotechnology and Reproduction and Director of Research Strategy and Development, School of Veterinary Science, University of Queensland and Visiting Scientist, CSIRO Livestock Industries.I currently hold a joint appointment in the School of Veterinary Sciences at the University of Queensland, where I am Professor of Animal Biotechnology and Reproduction and Director of Research Strategy and Development, and CSIRO Livestock Industries where I lead the Breed Engineering project in the Food Futures Flagship in CSIRO Livestock Industries.Within the University I am developing two major related research programs. The first of these builds on the work developed at Monash University within the ARC Centre of Excellence in Biotechnology and Development in which I remain a CI. These studies involve the isolation, characterization, culture and genetic manipulation of adult bovine testicular stem cells.
My interests grow out of a long term interest in male reproduction,fertilization and pre-implantation embryo development. More recently this has moved towards stem cells particularly their applications in livestock and in small animal veterinary medicine. My current funded projects include: A proteomic mapping of the bovine sperm surface (recently published in Proteomics) and identification of surface markers associated with several traits including fertility, sex determination and cryopreservation success Isolation of bovine spermatogonial stem cells and understanding the major factors which limit successful transplantation from Bos Taurus into Bos indicus recipients who’s own germ cells had been ablated by radiation of chemical treatment. Identifying bovine sperm proteins, other than PLC zeta, or micro RNAs which influence preimplantation embryo development. Isolation and characterisation of embryonic stem cell and induced pluripotent cells from livestock, dogs and wild felids and their use in assisted reproduction Identifying the major reasons for early stage pregnancy loss in Brahmin cattle raised in tropical Northern Australia Development of a contraceptive vaccine based on zona pellucida proteins for use in cattle to replace surgical speying.