Journal of Aging Science

Department of Medical Genetics, Bulgaria

Publications

• Research   
  POOL-SEQ Study of Bulgarian Centenarians Highlights the Relevance for Human Longevity of Gene Expression Pathways
  Author(s): Dimitar Serbezov, Lubomir Balabanski, Sena Karachanak-Yankova, Radoslava Vazharova, Desislava Nesheva, Zora Hammoudeh, Rada Staneva, Marta Mihaylova, Vera Damyanova, Olga Antonova, Dragomira Nikolova, Savina Hadjidekova and Draga Toncheva*
  
  In human longevity studies a large number of genetic variants with small effects have been identified, but these are not easily replicable in different populations. We have performed whole-exome sequencing of two DNA pools from: 32 Bulgarian centenarians and 61 young healthy controls, respectively. A total of 59935 filtered variants were discovered, 216 of which were included in Longevity Map database which lists 2843 longevity associated variants. Using Fisher’s exact test, 22 of these variants showed significantly higher allele frequency in the centenarian compared to the control pool and are thus positively associated with longevity. Other 24 variants had significantly higher frequency in the controls and could be considered as negatively associated with longevity. The risk C allele in rs429358 of the APOE gene was only detected in the control pool and with lower frequency co.. View more»
  

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