Journal of Diabetes & Metabolism

ISSN - 2155-6156

Tomoyuki Koyama

Department of Food Chemistry and Functional Nutrition, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan

Publications

  • Research Article   
    Glucosinolate Sinigrin Improves Insulin Resistance to Suppress Glutathione Consumption in Type 2 Diabetic Mice
    Author(s): Thao Thi Phuong Truong and Tomoyuki Koyama*

    Background: Sinigrin, an aliphatic glucosinolate, is absorbed from the intestine as allyl isothiocyanate (AITC) and conjugated with glutathione (GSH) followed by excretion as an N-acetylcysteine (AITC-NAC) into the urine. AITC is the crucial metabolized form which reflects the occurring bioavailability of dietary sinigrin. However, whether the anti-diabetic effects of dietary sinigrin and the quantitative of metabolic parameters AITC and AITC-NAC remain unknown in the type 2 diabetes model (T2D). Methods: A total of mice were divided into 6 groups: (i) normal control (ii) diabetic control, (iii) normal + 15 (μmol sinigrin/kg BW for all), (iv) diabetes + 15, (v) normal + 30 and (vi) diabetes + 30. After oral administration of sinigrin for 21 days, plasma, tissue, and urine were collected for analysis of metabolic parameters. .. View More»

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