Journal of Vaccines & Vaccination

Journal of Vaccines & Vaccination
Open Access

ISSN: 2157-7560

Shahana A. Choudhury

Department of Pediatrics, Meharry Medical College, 1005 D.B Todd Blvd, Nashville, TN 37208, USA

  • Research Article   
    Seroprevalence of Antibodies to Tetanus Toxoid and Diphtheria Toxoid in Perinatally Human Immunodeficiency Virus (HIV) - Infected Children and Adolescents
    Author(s): Shahana A. Choudhury* and FazleMatin

    Introduction: Although data presented in this study is a few years old, the author believes it is important to review in this era of the COVID-19 pandemic in order to underscore the importance of timely immunization of all children, particularly those who are HIV-infected. Even in the era of Highly Active Antiretroviral Therapy (HAART), HIVinfected individuals are at a higher risk of complications from vaccine-preventable diseases than the uninfected. Methods: Anti-diphtheria and anti-tetanus antibodies (correlate of protection: antibody level>0.1 IU/ml) were assessed by ELISA in 29 HIV-infected and 20 uninfected children. Results: HIV- infected children were significantly more likely to have lower levels of antibody to diphtheria toxic when compared to their uninfected counterparts, in both the four dose (p=0.0.. Read More»

    Abstract HTML PDF