Pharmaceutica Analytica Acta

Pharmaceutica Analytica Acta
Open Access

ISSN: 2153-2435

+44 1202068036

Roopali M. Shetake

Department of Pharmaceutics, KLE College of Pharmacy, Karnataka, India

  • Research Article   
    Development and Evaluation of Curcumin Floating Tablets
    Author(s): Kishor A. Bellad, Basavaraj K. Nanjwade*, Arindam Basu Sarkar, Teerapol Srichana and Roopali M. Shetake

    In the present study, curcumin an anti-inflammatory agent, was first complexed with the soluplus by hot melt extrusion machine to enhance the solubility of curcumin and was formulated into floating tablets by direct compression method. Tablets were formulated using various grades of Hydroxypropyl methylcellulose (HPMC) polymers and sodium bicarbonate as gas generating agent. Preformulation and micromeritic studies were performed. The floating tablets were evaluated for their physico-chemical properties, in-vitro release, in-vivo floating property, pharmacokinetic and stability studies. Formulations were found uniform with respect to thickness (5.11 to 5.27 mm) and hardness (4.4 to 4.8 kg/cm2). The friability (0.27 to 0.53 %), weight variation (1.28-1.89%) and Drug content (97.84 to 99.46 %). The order of swelling index of HPMC was found to be K100M > K15M > K.. Read More»
    DOI: 10.35248/2153-2435.20.11.622

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