Regina Linder

Department of Medical Laboratory Sciences, Hunter College, Manhattan, New York, USA

Publications
  • Research Article   
    Cooperative Cytotoxins: A New Look at an Old Observation of Bacterial Crosstalk
    Author(s): Regina Linder* and Camille D. McIntyre

    Cooperative (or synergistic) hemolysis, the ability of two bacterial species to jointly lyse erythrocytes, has long been recognized as a helpful tool in the identification of common pathogens (i.e. the CAMP reaction between Streptococcus agalactiae and Staphylococcus aureus). However, to examine these biological partnerships separately from their use in the diagnostic lab provides new perspectives on toxicity to host tissue during infections and in health. Many examples of such pairings exist, and typically reflect the sequential action of a phospholipase (e.g., PLC from Staphylococcus aureus or Clostridium perfringens), followed by a second bacterial toxin acting on the altered membrane, e.g. the CAMP protein of group B streptococci, or the cholesterol oxidase of Rhodococcus equi. Commonly occurring cooperative cytotoxic part.. View more»

    DOI: 10.35248/2155-9597.19.10.362

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