Journal of Thrombosis and Circulation: Open Access

Department of Pharmacy, Christiana Care Health System, 4755 Ogletown Stanton Rd, Newark, DE 19713, USA

Publications

• Research   
  An Analysis of Outcomes after Administration of Four Factor Prothrombin Complex Concentrate for Urgent Reversal of Anticoagulation in Patients with Intracranial Hemorrhage
  Author(s): Painter MD*, Farrell MS, Wiedner MC, Perza M, Caplan RJ and Cipolle MD
  
  Introduction: Four factor prothrombin complex concentrate (PCC4) and vitamin K are used for urgent reversal of coagulopathy in patients with intracranial hemorrhage while on vitamin K antagonists (VKA) and factor Xa inhibitors. Evaluation in a ‘real world’ population has not been performed. Material and methods: Retrospective review of 110 patients with hemorrhagic stroke (n=75) or traumatic ICH (n= 35) at a comprehensive stroke and trauma center, from 9/2013 and 12/2016. PCC4 was used to reverse coagulopathy in VKA-related ICH in 75 patients and for factor Xa inhibitors in 35 patients. Results: Between patient groups taking VKA and factor Xa inhibitors, there was no difference in Glasgow Coma Scale (GCS), or Marshall and Rotterdam CT scores. No differences were noted between VKA and factor Xa inhibitor.. View more»
  

  Abstract PDF