Pharmaceutica Analytica Acta

Pharmaceutica Analytica Acta
Open Access

ISSN: 2153-2435

+44 1202068036

Nanam Rajani

St. Peters Institute of Pharmaceutical Sciences, Hanamkonda, Warangal, Telangana, India

  • Research Article   
    Solubility Enhancement of Ritonavir: Co-Crystallization
    Author(s): Narala Sagar*, Ampati Rahul and Nanam Rajani

    The main objective of this work is to explore co-crystallization approach for increasing solubility of an antiretroviral drug, Ritonavir (RTN). In this study, different co-formers with different functional groups like carboxylic acid andacid amidewere tried in ratio of 1:1, 1:2 and 1:3 (RTN:Co-former) using neat grinding method. Co-formers used were citric acid (CIT) and adipic acid (ADP). The co-crystals formed were characterized by melting point determination, Fourier-transform infrared (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and solubility studies. Co-crystals of drug with CIT and ADP showed the improved dissolution profile when compared to the pure RTN. Melting point, DSC, FTIR spectra of co-crystals were different than pure drug and co-formers indicating their interaction. XRD patterns of co-crystals were not completely amorphous but less intense .. Read More»
    DOI: 10.35248/2153- 2435.20.11.621

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